Recommended by professionals:

“Autoimmune blood tests detect autoantibodies that mistakenly attack healthy cells in your body. Symptoms can often feel vague, frustrating, and difficult to explain. Autoimmune testing is a well-established clinical tool that helps provide a clearer picture of an immune system.”

Dr Gareth James

MBBS, DRCOG, DFFP, MRCGP

9,000+ 5-star reviews

Autoimmune & Immune Response Test

Understand your immune system activity from home. This test analyses 18 clinically relevant autoimmune markers.
£99.99 £124.99
Sale
  • Feature Icon 18 clinically relevant markers tested
  • Feature Icon Finger prick blood sample
  • Feature Icon Easy home testing
  • Feature Icon Results within 3 working days
  • Feature Icon Free shipping & sample returns
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Home-to-lab fast results

Home-to-lab fast results

FREE shipping

FREE shipping

100% confidential service

100% confidential service

Certified lab testing

Certified lab testing

Home-to-lab fast results

Home-to-lab fast results

FREE shipping

FREE shipping

100% confidential service

100% confidential service

Certified lab testing

Certified lab testing

Recommended by professionals:

“Autoimmune blood tests detect autoantibodies that mistakenly attack healthy cells in your body. Symptoms can often feel vague, frustrating, and difficult to explain. Autoimmune testing is a well-established clinical tool that helps provide a clearer picture of an immune system.”

Dr Gareth James

MBBS, DRCOG, DFFP, MRCGP

What is an Autoimmune & Immune Response Test?

An ANA (antinuclear antibody) test is a widely used clinical tool that helps assess whether the immune system may be reacting against the body’s own cells. It is commonly used as an initial investigation when autoimmune conditions are suspected.

However, autoimmune conditions can be complex and difficult to identify. Symptoms such as fatigue, joint discomfort and inflammation often overlap with other health concerns, and immune activity can involve multiple pathways beyond those assessed by ANA alone.

That’s why this panel goes beyond traditional ANA-only screening, analysing 18 clinically relevant markers to provide a broader overview of immune system activity across:

✔ Systemic immune activity
✔ Connective tissue markers
✔ Muscle & joint-related markers
✔ Gland & organ-related responses

By combining multiple markers into a single panel, this test is designed to provide wider insight into autoimmune-related immune activity and more structured result categorisation.

Autoimmune & Immune Response Test

How does it work?

Activate your test online

Activate your test online using your unique reference number

Take your sample at home

Using one of the single-use lancets, prick your index finger and carefully collect your blood sample. Follow the detailed instructions in your test kit for guidance.

Send your blood sample to our laboratory

Package and send your sample to our fully accredited laboratory. A postage-paid returns envelope is included within your test kit.

Receive your results

You will be notified by email as soon as your results are ready, this will be within 3 working days from the laboratory receiving your sample.

Activate your test online
Take your sample at home
Send your blood sample to our laboratory
Receive your results

Feeling constantly run down with no clear reason?

A clinically recognised test, made more accessible

ANA testing is commonly used within the NHS as a first step in investigating autoimmune conditions such as lupus. Autoimmune conditions can be complex and often require multiple tests to help understand underlying immune system activity.

UK clinical guidelines support the use of autoantibody testing when autoimmune conditions are suspected.

Autoantibody panels are widely used in rheumatology to assess conditions affecting joints, connective tissues, and the immune system.

Important information

This test is not intended to diagnose medical conditions but provides insights that may support further investigation with a qualified healthcare professional.

What’s tested

  • 1. Histidyl-tRNA Synthetase (Jo-1)

    May be linked to immune-related muscle inflammation, which can contribute to weakness or fatigue.

  • 2. PM-Scl 100

    Associated with combined muscle and connective tissue immune activity.

  • 3. Centromere Protein B

    Linked to immune responses affecting circulation and connective tissue, including the skin.

  • 4. Scl-70

    Associated with deeper connective tissue activity that may affect skin and internal structures.

  • 5. Ro/SS-A (60kDa)

    Linked to immune activity that may affect energy levels and gland function (e.g. dryness).

  • 6. Ro/SS-A (52kDa)

    Similar to the above, often associated with fatigue and immune system imbalance.

  • 7. La/SS-B

    Associated with immune responses that can affect moisture-producing glands (eyes, mouth).

  • 8. M2 (Mitochondrial Antibody)

    Linked to immune activity that may affect liver function.

  • 9. dsDNA

    A key marker associated with systemic immune activity affecting multiple areas of the body.

  • 10. Nucleosome

    Indicates immune responses targeting core cell structures.

  • 11. Histone

    Another marker of immune activity directed at cellular components

  • 12. Proliferating Cell Nuclear Antigen (PCNA)

    Linked to immune activity during cell repair and replication.

  • 13. Ribosomal Phosphoprotein P0

    Associated with immune responses that may affect neurological or systemic function.

  • 14. Sm (Smith Antigen)

    A specific marker associated with systemic immune activity.

  • 15. U1-snRNP 68/70 kDa

    Linked to broader immune responses affecting multiple systems.

  • 16. U1-snRNP A

    Associated with overlapping immune activity patterns.

  • 17. U1-snRNP C

    Part of a group of markers linked to complex immune responses

  • 18. RNP/Sm

    Indicates combined immune activity across multiple pathways.

  • 1. Histidyl-tRNA Synthetase (Jo-1)

    May be linked to immune-related muscle inflammation, which can contribute to weakness or fatigue.

  • 2. PM-Scl 100

    Associated with combined muscle and connective tissue immune activity.

  • 3. Centromere Protein B

    Linked to immune responses affecting circulation and connective tissue, including the skin.

  • 4. Scl-70

    Associated with deeper connective tissue activity that may affect skin and internal structures.

  • 5. Ro/SS-A (60kDa)

    Linked to immune activity that may affect energy levels and gland function (e.g. dryness).

  • 6. Ro/SS-A (52kDa)

    Similar to the above, often associated with fatigue and immune system imbalance.

  • 7. La/SS-B

    Associated with immune responses that can affect moisture-producing glands (eyes, mouth).

  • 8. M2 (Mitochondrial Antibody)

    Linked to immune activity that may affect liver function.

  • 9. dsDNA

    A key marker associated with systemic immune activity affecting multiple areas of the body.

  • 10. Nucleosome

    Indicates immune responses targeting core cell structures.

  • 11. Histone

    Another marker of immune activity directed at cellular components

  • 12. Proliferating Cell Nuclear Antigen (PCNA)

    Linked to immune activity during cell repair and replication.

  • 13. Ribosomal Phosphoprotein P0

    Associated with immune responses that may affect neurological or systemic function.

  • 14. Sm (Smith Antigen)

    A specific marker associated with systemic immune activity.

  • 15. U1-snRNP 68/70 kDa

    Linked to broader immune responses affecting multiple systems.

  • 16. U1-snRNP A

    Associated with overlapping immune activity patterns.

  • 17. U1-snRNP C

    Part of a group of markers linked to complex immune responses

  • 18. RNP/Sm

    Indicates combined immune activity across multiple pathways.

Most ANA tests check 1 or 2 markers. Ours checks 18.

Standard ANA screening (1 or 2 markers)
18-marker autoimmune panel 18-marker autoimmune panel
Initial autoimmune investigation
Broader multi-marker overview
Limited marker scope
18 clinically relevant markers
Often focused on a single screening pathway
Multiple autoimmune response categories
General first-step assessment
Systemic, connective tissue, joint & organ-related insights
May require additional follow-up testing
Wider autoimmune activity assessment in one panel

Frequently asked questions

Answering your questions on the Autoimmune & Immune Response Test

An ANA (antinuclear antibody) test measures antibodies that may indicate your immune system is reacting against your own body. It is commonly used in clinical settings to help investigate autoimmune conditions.

Autoimmune tests analyse specific antibodies in your blood that may be linked to immune system activity affecting joints, muscles, skin, glands, and internal organs.

Yes. ANA testing is commonly used within the NHS as part of the investigation process when autoimmune conditions such as lupus are suspected.

Quality you can trust

All our labs or partner labs hold UKAS, ISO9001, ISO13485, ISO15189 or ISO17025 accreditations.
ISO compliant
UKAS accredited labs
Tested in UK lab
Certified Nutritional Therapists
ISO compliant
UKAS accredited labs
Tested in UK lab
Certified Nutritional Therapists

Clinically recognised testing you can trust

Understanding what may be influencing your immune health starts with reliable science. Our Autoimmune & Immune Response Test uses advanced autoantibody blood analysis - a clinically recognised testing approach used by healthcare professionals to support the investigation of autoimmune conditions.

Autoantibody testing, including ANA (Antinuclear Antibody) and associated markers, is recognised within NHS clinical pathways as part of the assessment process for suspected autoimmune connective tissue conditions when reviewed alongside symptoms and medical history.

Unlike basic screening tests that may only measure a limited number of markers, our advanced laboratory technology analyses 18 key autoimmune markers from one simple home blood collection, providing broader insights into your immune response with convenient access to expert support.

Reviewed by healthcare professionals

“Understanding changes within your immune system can be an important first step for people experiencing unexplained symptoms such as ongoing fatigue, joint discomfort, inflammation, skin changes or other concerns associated with autoimmune conditions.

Autoantibody blood testing, including ANA and associated markers, is a clinically recognised laboratory method used to support the investigation of autoimmune responses. The Check My Body Health Autoimmune & Immune Response Test provides valuable insight by analysing 18 key autoimmune markers from a single home blood sample.

Combined with professional interpretation and personalised guidance, advanced autoimmune testing can help you better understand your results and support informed conversations about your health and next steps.”

Dr Gareth James
Medical Director | MBBS, DRCOG, DFFP, MRCGP

Clinically recognised testing you can trust

Understanding what may be influencing your immune health starts with reliable science. Our Autoimmune & Immune Response Test uses advanced autoantibody blood analysis - a clinically recognised testing approach used by healthcare professionals to support the investigation of autoimmune conditions.

Autoantibody testing, including ANA (Antinuclear Antibody) and associated markers, is recognised within NHS clinical pathways as part of the assessment process for suspected autoimmune connective tissue conditions when reviewed alongside symptoms and medical history.

Unlike basic screening tests that may only measure a limited number of markers, our advanced laboratory technology analyses 18 key autoimmune markers from one simple home blood collection, providing broader insights into your immune response with convenient access to expert support.

Reviewed by healthcare professionals

“Understanding changes within your immune system can be an important first step for people experiencing unexplained symptoms such as ongoing fatigue, joint discomfort, inflammation, skin changes or other concerns associated with autoimmune conditions.

Autoantibody blood testing, including ANA and associated markers, is a clinically recognised laboratory method used to support the investigation of autoimmune responses. The Check My Body Health Autoimmune & Immune Response Test provides valuable insight by analysing 18 key autoimmune markers from a single home blood sample.

Combined with professional interpretation and personalised guidance, advanced autoimmune testing can help you better understand your results and support informed conversations about your health and next steps.”

Dr Gareth James
Medical Director | MBBS, DRCOG, DFFP, MRCGP

Approved by registered doctors and nutrionists