-
1. Histidyl-tRNA Synthetase (Jo-1)
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2. PM-Scl 100
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3. Centromere Protein B
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4. Scl-70
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5. Ro/SS-A (60kDa)
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6. Ro/SS-A (52kDa)
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7. La/SS-B
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8. M2 (Mitochondrial Antibody)
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9. dsDNA
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10. Nucleosome
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11. Histone
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12. Proliferating Cell Nuclear Antigen (PCNA)
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13. Ribosomal Phosphoprotein P0
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14. Sm (Smith Antigen)
-
15. U1-snRNP 68/70 kDa
-
16. U1-snRNP A
-
17. U1-snRNP C
-
18. RNP/Sm
What is an Autoimmune & Immune Response Test?
An ANA (antinuclear antibody) test is a widely used clinical tool that helps assess whether the immune system may be reacting against the body’s own cells. It is commonly used as an initial investigation when autoimmune conditions are suspected.
However, autoimmune conditions can be complex and difficult to identify. Symptoms such as fatigue, joint discomfort and inflammation often overlap with other health concerns, and immune activity can involve multiple pathways beyond those assessed by ANA alone.
That’s why this panel goes beyond traditional ANA-only screening, analysing 18 clinically relevant markers to provide a broader overview of immune system activity across:
✔ Systemic immune activity
✔ Connective tissue markers
✔ Muscle & joint-related markers
✔ Gland & organ-related responses
By combining multiple markers into a single panel, this test is designed to provide wider insight into autoimmune-related immune activity and more structured result categorisation.
Who is this test for?
If you’ve been experiencing ongoing symptoms with no clear answers, this test helps uncover whether your immune system may be reacting abnormally so you can take the next step with confidence.
You may benefit if you experience:
Ongoing fatigue or low energy
Joint pain, stiffness, or discomfort
Brain fog or difficulty concentrating
Inflammation or swelling
Skin flare-ups or ongoing skin irritation
Muscle aches or weakness
Digestive discomfort
Feeling constantly run down with no clear reason?
A clinically recognised test, made more accessible
ANA testing is commonly used within the NHS as a first step in investigating autoimmune conditions such as lupus. Autoimmune conditions can be complex and often require multiple tests to help understand underlying immune system activity.
UK clinical guidelines support the use of autoantibody testing when autoimmune conditions are suspected.
Autoantibody panels are widely used in rheumatology to assess conditions affecting joints, connective tissues, and the immune system.
This test is not intended to diagnose medical conditions but provides insights that may support further investigation with a qualified healthcare professional.
What’s tested
Most ANA tests check 1 or 2 markers. Ours checks 18.
Frequently asked questions
Answering your questions on the Autoimmune & Immune Response TestAn ANA (antinuclear antibody) test measures antibodies that may indicate your immune system is reacting against your own body. It is commonly used in clinical settings to help investigate autoimmune conditions.
Autoimmune tests analyse specific antibodies in your blood that may be linked to immune system activity affecting joints, muscles, skin, glands, and internal organs.
Yes. ANA testing is commonly used within the NHS as part of the investigation process when autoimmune conditions such as lupus are suspected.
Common symptoms include fatigue, joint pain, brain fog, skin issues, and ongoing inflammation. These symptoms can be difficult to diagnose and often overlap with other conditions.
Many standard tests analyse a limited number of markers. This test checks 18 markers, providing a broader view of immune system activity.
No. This test does not diagnose conditions but helps identify patterns of immune activity that may support further investigation.
You may consider testing if you have persistent symptoms such as fatigue, inflammation, or unexplained health issues that have not been fully explained.
Yes. Some autoimmune markers are not included in routine blood tests, so this test may provide additional insight.
Your sample is analysed in a certified laboratory using validated methods. The test provides reliable insights into immune system activity.
Yes. Many autoimmune conditions present with vague or overlapping symptoms, which can make diagnosis complex and require multiple tests.
Testing multiple markers helps build a broader picture of immune system activity rather than relying on a single indicator.
This is a home-to-lab test. You collect your sample at home and send it to our certified laboratory for analysis.
Results are typically available within 3 days after your sample reaches the lab.
Fatigue can have many causes. This test may help identify whether immune system activity could be a contributing factor.
Yes. It can be used as part of a broader approach to understanding your health over time.
No. This test is available directly to you without the need for a referral.
You will receive guidance with your report, including suggested next steps based on your results.
This test is intended for adults looking to better understand their immune system activity.
We remove unnecessary costs like clinic visits and pass those savings on while still delivering comprehensive lab analysis.
The best autoimmune test is one that combines comprehensive marker coverage, clinically recognised biomarkers, high-quality laboratory analysis, and professional guidance to help you understand your results. The Check My Body Health Autoimmune & Immune Response Test has been designed to provide deeper insight into possible autoimmune activity by analysing 18 key ANA-associated biomarkers commonly used by healthcare professionals when investigating autoimmune conditions. Unlike basic ANA screening tests that may only indicate whether antinuclear antibodies are present, our advanced ANA profile provides a more detailed analysis across multiple antibody markers associated with different autoimmune responses. Our test includes: ✓ 18 clinically recognised autoimmune markers Analyses a broad panel of ANA-associated antibodies, including markers commonly investigated in relation to autoimmune connective tissue conditions such as lupus, Sjögren’s syndrome, systemic sclerosis, and other autoimmune disorders. ✓ Advanced laboratory testing you can trust Your sample is analysed in a highly accredited laboratory operating to internationally recognised quality standards, including UKAS accreditation, ensuring accurate and reliable testing processes. ✓ Simple home-to-lab convenience Collect your blood sample easily from home using our finger-prick collection kit and return it securely to our laboratory for professional analysis. ✓ Clear, easy-to-understand results Your personalised report explains your results clearly, helping you understand whether each marker shows: Normal Slight Elevation Moderate Elevation High Elevation ✓ Expert support after your results Understanding autoimmune markers can feel complicated, which is why our test includes access to professional support from our experienced healthcare team, including GPs and registered nutrition professionals, helping you understand your results and your next steps. If you are experiencing ongoing symptoms such as persistent fatigue, joint discomfort, muscle aches, or unexplained health concerns, an advanced ANA profile can provide valuable information to support further conversations about your health. Our Autoimmune & Immune Response Test combines 18 ANA-associated biomarkers, UKAS-accredited laboratory analysis, convenient home collection, and professional aftercare support, making it one of the most comprehensive at-home autoimmune testing options available.
The best at-home autoimmune test should combine the convenience of collecting your sample from home with the confidence of professional laboratory analysis, clinically recognised biomarkers, and expert support to help you understand your results. The Check My Body Health Autoimmune & Immune Response Test offers a simple home-to-lab testing experience while providing detailed insight into possible autoimmune activity through an advanced 18-marker ANA profile. Our at-home autoimmune test includes: ✓ Convenient home blood collection Complete your test from the comfort of your own home using an easy finger-prick blood collection kit. Simply collect your sample and return it securely to our accredited laboratory for analysis. ✓ 18 autoimmune biomarkers analysed Unlike basic screening options, our advanced ANA profile analyses 18 clinically recognised autoimmune markers associated with different autoimmune responses, helping provide a broader picture of your immune health. ✓ Professional laboratory testing Your sample is analysed using advanced laboratory technology within a UKAS-accredited laboratory, providing trusted results without needing to visit a clinic. ✓ Easy-to-understand results report Receive a clear digital report explaining your autoimmune marker results, including whether each marker is: Normal Slight Elevation Moderate Elevation High Elevation ✓ Support from healthcare professionals Your results are only the beginning. Our team of GPs and nutrition professionals are available to help explain your results, answer questions, and support you with personalised next steps. An at-home autoimmune test can be a convenient first step for people looking to better understand potential autoimmune markers, especially when experiencing ongoing symptoms such as fatigue, joint discomfort, muscle aches, or unexplained health concerns. The Check My Body Health Autoimmune & Immune Response Test is a convenient at-home autoimmune test that analyses 18 ANA-associated biomarkers through a UKAS-accredited laboratory, with simple finger-prick collection and professional support from GPs and nutrition experts.
Yes, autoimmune testing can now be completed from home using a simple blood collection kit, with your sample then analysed by a professional laboratory. The Check My Body Health Autoimmune & Immune Response Test allows you to collect your sample conveniently at home while still benefiting from advanced laboratory testing and expert support. Our home autoimmune test includes: ✓ Simple finger-prick blood collection Collect your blood sample at home using an easy-to-follow testing kit, without needing to book a clinic appointment or travel to a testing centre. ✓ Professional laboratory analysis Your sample is securely returned to our UKAS-accredited laboratory, where it is analysed using advanced testing technology designed to detect specific autoimmune-related antibodies. ✓ 18 ANA-associated markers tested Our advanced autoimmune panel measures 18 clinically recognised biomarkers commonly investigated by healthcare professionals when assessing possible autoimmune activity, providing greater insight than a basic ANA screen alone. ✓ Private and secure digital results Receive your results online in a clear, easy-to-understand report showing your antibody responses across each marker. We also include a helpful guide with a full explanation of every marker tested and what it might impact in your body. ✓ Expert guidance after testing Autoimmune results can sometimes be complex to interpret. That’s why we provide access to our professional team, including GPs and nutrition experts, who can help explain your results and guide your next steps. Taking an autoimmune test at home provides a convenient way to gain additional insight into your immune health, particularly if you are experiencing symptoms such as ongoing tiredness, joint discomfort, muscle aches, or unexplained wellness concerns.
Yes, autoimmune testing can now be completed from home using a simple blood collection kit, with your sample then analysed by a professional laboratory. The Check My Body Health Autoimmune & Immune Response Test allows you to collect your sample conveniently at home while still benefiting from advanced laboratory testing and expert support. Our home autoimmune test includes: ✓ Simple finger-prick blood collection Collect your blood sample at home using an easy-to-follow testing kit, without needing to book a clinic appointment or travel to a testing centre. ✓ Professional laboratory analysis Your sample is securely returned to our UKAS-accredited laboratory, where it is analysed using advanced testing technology designed to detect specific autoimmune-related antibodies. ✓ 18 ANA-associated markers tested Our advanced autoimmune panel measures 18 clinically recognised biomarkers commonly investigated by healthcare professionals when assessing possible autoimmune activity, providing greater insight than a basic ANA screen alone. ✓ Private and secure digital results Receive your results online in a clear, easy-to-understand report showing your antibody responses across each marker. ✓ Expert guidance after testing Autoimmune results can sometimes be complex to interpret. That’s why we provide access to our professional team, including GPs and nutrition experts, who can help explain your results and guide your next steps. Taking an autoimmune test at home provides a convenient way to gain additional insight into your immune health, particularly if you are experiencing symptoms such as ongoing tiredness, joint discomfort, muscle aches, or unexplained wellness concerns.
An ANA test (Antinuclear Antibody test) is a type of autoimmune blood test that looks for specific antibodies produced by the immune system. These antibodies may appear when the immune system mistakenly reacts against the body’s own cells, which can happen in some autoimmune conditions. The term “autoimmune test” is broader and may refer to a range of blood tests used to investigate immune system activity, inflammation, or specific autoimmune-related antibodies. A standard ANA screening test typically identifies whether antinuclear antibodies are present, whereas an advanced ANA profile provides more detailed information by analysing multiple specific antibody markers. The Check My Body Health Autoimmune & Immune Response Test goes beyond a basic ANA screen by analysing 18 clinically recognised ANA-associated biomarkers, providing deeper insight into different autoimmune antibody patterns. Our advanced ANA profile includes markers associated with investigations into autoimmune conditions such as: • Systemic Lupus Erythematosus (SLE) – including dsDNA, Sm, Nucleosome and Histone antibodies • Sjögren’s Syndrome – including Ro/SSA and La/SSB antibodies • Systemic Sclerosis – including Scl-70 and CENP-B antibodies • Mixed Connective Tissue Disease – including U1-snRNP antibodies • Other autoimmune connective tissue investigations Choosing an advanced ANA profile instead of a basic ANA screen may provide a more comprehensive view of specific autoimmune markers, helping you and your healthcare professional better understand your results. The Check My Body Health Autoimmune & Immune Response Test combines: • 18 autoimmune-related biomarkers • Simple home blood collection • UKAS-accredited laboratory analysis • Clear personalised results • Access to professional support from our team of GPs and nutrition specialists The difference between an ANA test and an autoimmune test is that ANA testing is one type of autoimmune investigation. A basic ANA test usually checks whether antinuclear antibodies are present, while an advanced ANA profile can analyse multiple specific autoimmune biomarkers. The Check My Body Health Autoimmune & Immune Response Test measures 18 ANA-associated markers through a UKAS-accredited laboratory.
The accuracy of a home autoimmune blood test depends on three important factors: the quality of the sample collected, the technology used for analysis, and the standards of the laboratory performing the test. The Check My Body Health Autoimmune & Immune Response Test combines the convenience of home sample collection with professional laboratory analysis using an advanced ANA testing system. Unlike simple screening tests, the ANA system our laboratory uses is designed to analyse multiple autoimmune-related antibodies in a single test, helping provide a more detailed understanding of your immune response. Our test provides confidence through: ✓ Advanced ANA Technology Our ANA Profile is an in-vitro diagnostic (IVD) test developed to detect autoantigen-specific IgG antibodies associated with autoimmune investigations. It allows the simultaneous analysis of 18 different autoimmune markers from one blood sample. The panel includes clinically recognised autoimmune biomarkers such as: • dsDNA • Nucleosome • Histone • Sm • U1-snRNP • Ro/SSA • La/SSB • Scl-70 • CENP-B • Jo-1 • PM-Scl These markers are commonly used by healthcare professionals when investigating autoimmune connective tissue conditions. ✓ Intelligent Q-Smart Laboratory Analysis Samples are analysed using PROTIA’s Q-Smart scanning and interpretation technology, which supports the evaluation of immunoblot, line assay, and lateral flow testing formats. The Q-Smart system helps provide: Automated scanning of test results Standardised interpretation Reduced manual reading variation Consistent laboratory reporting ✓ Professional Laboratory Quality Standards Your sample is analysed in a UKAS-accredited laboratory following strict quality-controlled processes. Accurate autoimmune testing requires more than just advanced technology — it requires: Validated laboratory procedures Quality control processes Trained laboratory scientists Reliable reporting systems ✓ More Insight Than a Basic ANA Screen A traditional ANA screen is often used as an initial investigation to detect the presence of antinuclear antibodies. The Check My Body Health Autoimmune & Immune Response Test goes further by measuring 18 individual ANA-associated markers, providing more detailed antibody information that may help identify different autoimmune patterns. ✓ Professional Support After Your Results Autoimmune results can be complex and should always be interpreted alongside your symptoms and medical history. That’s why your results include access to our professional support team, including GPs and nutrition specialists, who can help explain your results and advise on appropriate next steps. The Check My Body Health Autoimmune & Immune Response Test uses PROTIA ANA Profile 18 technology to analyse 18 clinically recognised autoimmune markers through a UKAS-accredited laboratory. Combining convenient home blood collection, advanced Q-Smart laboratory analysis, and professional healthcare support, it provides a comprehensive way to gain insight into autoimmune-related antibodies.
Joint pain, stiffness, and inflammation can have many possible causes, including injury, lifestyle factors, infection, inflammation, and in some cases autoimmune activity which is where the immune system mistakenly reacts against the body’s own tissues. If you are experiencing persistent or unexplained joint discomfort, an autoimmune blood test may help provide additional insight by checking for specific antibodies commonly investigated in autoimmune conditions. The Check My Body Health Autoimmune & Immune Response Test analyses 18 clinically recognised ANA-associated biomarkers that may be linked to autoimmune responses affecting the joints, muscles, skin, and connective tissues. Our advanced ANA profile includes markers associated with investigations into autoimmune conditions that can involve joint symptoms, including: dsDNA, Sm, Nucleosome & Histone antibodies – commonly investigated in relation to Systemic Lupus Erythematosus (SLE), which may include symptoms such as joint pain, fatigue, and inflammation. Ro/SSA & La/SSB antibodies – associated with investigations into Sjögren’s Syndrome and other connective tissue conditions. U1-snRNP antibodies – commonly assessed when investigating Mixed Connective Tissue Disease, which can involve joint and muscle symptoms. Scl-70, CENP-B & PM-Scl antibodies – used in investigations relating to systemic sclerosis and autoimmune connective tissue disorders. Our test provides: ✓ 18 autoimmune-related markers tested A more detailed antibody profile compared with a basic ANA screening test. ✓ Simple home blood collection Collect your sample conveniently at home using an easy finger-prick kit. ✓ UKAS-accredited laboratory analysis Your sample is processed using advanced laboratory technology and strict quality standards. ✓ Expert support after your results Our professional team of GPs and nutrition specialists can help explain your results and support your next steps. While an autoimmune test cannot diagnose the cause of joint pain by itself, it can provide valuable information about autoimmune-related antibodies that may help guide further conversations about your health. If you have ongoing joint pain, stiffness, or inflammation, an autoimmune blood test may help identify whether specific autoimmune-related antibodies are present. The Check My Body Health Autoimmune & Immune Response Test analyses 18 ANA-associated biomarkers linked with autoimmune investigations using UKAS-accredited laboratory testing and professional healthcare support.
A Normal result in your ANA test means that the specific autoimmune-related antibodies included within your test were not detected above the expected reference level at the time your sample was analysed. The Check My Body Health Autoimmune & Immune Response Test analyses 18 clinically recognised ANA-associated biomarkers commonly investigated when assessing possible autoimmune activity. If your results show as Normal, this means the laboratory did not identify elevated levels of the tested autoantibodies, including markers such as: dsDNA Nucleosome Histone Sm U1-snRNP Ro/SSA La/SSB Scl-70 CENP-B Jo-1 PM-Scl A normal result may indicate there is no evidence of increased activity across these specific autoimmune markers, which can provide helpful reassurance. However, autoimmune health can be complex. A normal ANA profile does not completely rule out every autoimmune condition, as: Some autoimmune conditions may involve antibodies not included within this panel Antibody levels can vary between individuals Symptoms, medical history, and other investigations may also be important If you continue to experience symptoms such as: Persistent fatigue Joint pain or stiffness Muscle aches Skin changes Ongoing unexplained symptoms It is important to discuss your health with an appropriate healthcare professional. With the Check My Body Health Autoimmune & Immune Response Test, you also have access to our professional support team, including GPs and nutrition specialists, who can help explain your results and discuss possible next steps.
An Elevated or Positive ANA test result means that one or more of the autoimmune-related antibodies analysed in your test were detected above the expected reference level. The Check My Body Health Advanced Autoimmune Blood Test measures 18 clinically recognised ANA-associated biomarkers. These antibodies are commonly investigated by healthcare professionals because they may be associated with increased immune system activity and certain autoimmune conditions. A positive result means that your immune system has produced detectable levels of specific autoantibodies. Autoantibodies are proteins made by the immune system that can mistakenly recognise parts of your own cells as a target. Depending on which marker is elevated, your results may provide insight into different autoimmune antibody patterns. Examples include: dsDNA, Sm, Nucleosome & Histone antibodies Commonly assessed in investigations relating to Systemic Lupus Erythematosus (SLE) Ro/SSA & La/SSB antibodies Commonly assessed in investigations relating to Sjögren’s Syndrome and connective tissue disorders Scl-70 & CENP-B antibodies Commonly assessed in investigations relating to Systemic Sclerosis U1-snRNP antibodies Commonly assessed in investigations relating to Mixed Connective Tissue Disease An elevated ANA result does not automatically mean you have an autoimmune disease. Autoimmune test results should always be considered alongside: Your symptoms Medical history Other blood test results Assessment from a healthcare professional Some people may have detectable autoimmune antibodies without developing a diagnosed autoimmune condition. If your result shows an elevated marker, our professional support team, including GPs and nutrition specialists, can help explain what your result means and guide you on appropriate next steps.
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